Complete range of molecular tests
Our comprehensive biochemistry testing portfolio using MRM-MS technology, enzymatic assays and novel biomarkers allow the detection and quantification of most Lysosomal storage diseases and metabolic diseases.
Single Gene Testing
with the availability of Sanger sequencing for the testing of over 4000 single disease related genes, we offer the world’s largest single gene testing portfolio, ensuring that no suspected disease remain undiagnosed. Our extensive experience in this field allows us to accurately and quickly perform testing with 100% coverage of all the regions of a disease related gene
Next generation sequencing panels
with over 200 NGS panels covering most bodily systems and disease categories, we are able to look at depth at any affected organ or the complete possible genetic subtypes of a disease. This allows the clinician to pinpoint the exact gene related to a clinical manifestation that is difficult to characterize in a suspected disease.
Powered by whole genome sequencing; Genomic panels allow the customization of service, the possible flexibility of the panel composition allows for highest diagnostic accuracy & utility. With unparalleled information content (HiSeqX technology), this allows for increased coverage of genic regions, reduced PCR Bias, high accuracy detection of CNVs and complex gene rearrangements Fastest time to results with no time or increased cost lost with step-wise analysis.
Whole exome sequencing
The combination of symptoms in certain patients does not allow the clinician to pinpoint a potential diagnosis. Therefore, ordering genetic testing becomes complex and might involve a long and costly stepwise diagnostic strategy. Most of the disease-causing mutations (about 85%) detected to date are located in the exonic regions of genes. Exons are the segments of DNA which encode for proteins. Our Whole exome sequencing service, offers a fast and cost-effective onestep solution which involves sequencing the entire coding region or exons, examining thousands of genes simultaneously
Whole genome sequencing
Whole genome sequencing (WGS) with CentoGenome provides the most comprehensive genetic testing available for the detection of genetic diseases. it identifies nearly all changes in a patient’s DNA by sequencing the entire coding and non-coding regions of the genome. It provides detailed information on the thousands of genes involved in normal growth and development and all of the ‘silent’ genome regions simultaneously
genome-wide array based solutions enable detection of known and novel structural aberrations such as copy number variations (CNVs) with a resolution down to 25kb, chromosomal imbalances, regions exhibiting loss/absence of heterozygosity (LOH), uniparental isodisomy (UDP) and even low-level mosaicism down to 30%. Compatible with wide range of samples including blood, DNA, fresh and frozen tissues, amniocytes, bone marrow aspirate and even formalin fixed paraffin embedded (FFPE) samples
Prenatal cases receive extreme attention at the genome outpost , we offer a turnaround time of seven working days for most prenatal analyses (known variants, deletion/duplication analysis, full gene sequencing) and of less than 15 working days for NGS (next generation sequencing) analyses (panels, Whole Exome, Whole genome and CGH array) for prenatal cases. All prenatal cases are assigned to a case specialist for close follow-up and monitoring.
Non-Invasive Prenatal Testing (NIPT)
Conventional prenatal testing for fetal chromosomal abnormality involves either chorionic villus sampling or amniocentesis. These procedures are highly invasive and carry an elevated risk of miscarriage. NIPT is a non-invasive test performed on a single maternal blood sample and combines the latest next generation sequencing technology with the highest quality medical reporting. It provides unparalleled accuracy and detection compared to other non-invasive testing methods – ultrasonography or nuchal translucency testing.
Comprehensive oncogenetic testing
Our comprehensive oncogenetic portfolio and carefully selected gene and designed panels addresses people with an identified cancer where the type of cancer or the family history warrant genetic analysis, or those who have no family history, no positive anamnesis and would like to know their risk of inherited cancer. Testing for all cancer involved genes are available such as breast, ovarian, colorectal, gastric, bowel, endometrial, pancreatic, melanoma, renal, and prostate cancer.
Mitochondrial disease testing
Mitochondrial disorders are a clinically heterogeneous group of disorders that often cause suffering and premature death. They arise as a result of dysfunction of the mitochondrial respiratory chain. By targeting nuclear encoded genes as well as mitochondrial encoded genes, this panel provides a comprehensive test in patients with a demonstrated mitochondrial deficiency on biopsy material or a suspicion of mitochondrial disorders based on the patient’s symptoms. Comprehensive mitochondrial disorders panel covers all protein coding genes on mitochondrial DNA (~96% coverage at >100x, detection of heteroplasmy down to 15%), along with complete coverage of mitochondrial genome and detection of all large mitochondrial gene deletions.
Newborn genetic testing
Up to one-third of all babies and children admitted to the ICU have a genetic disease. Newborns and children under 24 months presenting with life-threatening conditions need a fast and precise diagnosis to ensure rapid and efficient further diagnostic and therapeutic initiation. For many of them early identification can make the difference for their immediate and later health. Our comprehensive NGS panel that includes 808 genes, explicitly selected for the genetic testing of critically ill newborns and children under 24 months.
GET IN TOUCH
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The Genome Outpost
3rd circle – 48 Ibn Khaldoun Street
P.O box 831390
11183 Amman / Jordan